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Neurologist Howard Rosen correlated orbitofrontal loss with disinhibition and anterior cingulate damage with apathy. Meanwhile, on the right side of Holliday’s brain, her anterior temporal lobe, which is important for recognizing emotion and faces, was “paper thin,” Miller said. And yet, Miller said, her behavior was better than that of many patients. One man dropped his pants when he was having his blood drawn. Another, a retired surgeon, broke into his neighbor’s house to steal liquor and made sexual ad- 34 S c i e n t i f i c tions such as embarrassment, guilt and pride.
One man dropped his pants when he was having his blood drawn. Another, a retired surgeon, broke into his neighbor’s house to steal liquor and made sexual ad- 34 S c i e n t i f i c tions such as embarrassment, guilt and pride. Those require selfawareness and the ability to gauge how your own behavior stacks up against social norms — mental processes that such patients lack. ” vances toward women at a wedding rehearsal dinner. About half of FTD patients had engaged in antisocial behaviors that could (or did) get them arrested, including shoplifting, running a stoplight or driving while drunk.
Made by Singapore-based TauRx Pharmaceuticals, the drug is designed to block toxic tau protein buildup inside neurons. Holliday could be eligible for the experimental treatment, but with her substantial brain atrophy, it is unlikely to help much. The illness has shredded Holliday and Horowitz’s plans to retire to Mexico. Horowitz, who owns a construction firm in Napa Valley, now foresees a far bleaker journey. “I’m walking next to her and going all the way down to hell,” he told me last summer.